Use of Collagenase Clostridium histolyticum to Decrease Muscle Fiber Bundle Stiffness in Cerebral Palsy (2019)
Muscle stiffness in cerebral palsy has been associated with an increase in collagen in the space between muscle cells. If collagenase injections reduce stiffness, the need for surgical intervention
Supported Mobility Across the Lifespan in Cerebral Palsy: Joint Decision Making (2018)
Children and adults with CP might use a wheelchair, gait-trainer, or other weight-bearing device to aid in mobility. Such an aid is generally referred to as a “supported mobility
Muscle Stem Cell Dysfunction in Muscular Contractures in Children with Cerebral Palsy (2018)
This study evaluates the role of muscle stem cell dysfunction in the development of contractures in people with CP and its association with age and functionality. Muscle contractures are
Participation, Mobility, and Gait in Adults with Cerebral Palsy: Relationships with Childhood Factors (2018)
The goal of this longitudinal study is to investigate the changes in gait, mobility, and participation in adults with CP over a 20-year timespan. While significant work has been
Multimorbidity Risk Assessment and Prevention through Health-Promoting Behaviors in Adolescents and Adults with Cerebral Palsy (2017)
This study seeks to rigorously study the impacts of physical activity, sleep, and diet in preventing stroke and heart disease in patients with cerebral palsy. While such impacts are
Development and Validation of Epigenetic Signatures for Dyskenetic and Ataxic CP by Evaluation of DNA Collected from Peripheral Blood Samples and Determinations of DNA Methylation Pattern Differences Among Genes Associated with CP Diagnosis (2017)
This study looked for biomarkers in the DNA of people with dyskenetic and ataxic CP with a goal to help in CP diagnosis. A previous study by the group
Hypoxemia and White Matter Development in the Motor Outcomes of Extremely Preterm Infants (2017)
Researchers are non-invasively studying the brains of premature infants using advanced MRI techniques to determine the relationship between oxygen levels provided in the hospital and the impact on outcome
Neuroplastic Adaptations of Swallowing and Speech in Cerebral Palsy: a 2-Center Study to Identify New Treatment Targets (2017)
Researchers are examining the relationship between swallowing and speech mechanisms at several physiological levels. A better knowledge of typical and atypical development of swallow and speech could lead to
Contralaterally Controlled Functional Electrical Stimulation and Hand Therapy Video Games for Hemiplegic Cerebral Palsy (2016)
Individuals with CP often need to strengthen their muscles to participate in daily life. Few therapies help individuals strengthen their muscles on only one side. This grant seeks to
Patient Reported Outcomes in Cerebral Palsy (2016)
Appropriate treatment of CP requires that all symptoms of CP be addressed. This grant seeks to determine the nature of bladder-related symptoms individuals with CP face, in the hopes